“Chris McCurdy was a pioneer in the area of kratom research 10 years ago,” McMahon said. “This NIDA grant shows interest in the potential of kratom-based medicines, as well as concerns over the potential misuse of kratom-related substances.”
With new special research funding for kratom made possible by this and other grants, the number of scientists on the research team and infrastructure to study kratom for pain have expanded. Quantities of samples that once took two to three months to generate can now be available in just one week.
The next stage of university of florida kratom research involves identifying the pharmacology of its chemicals. Bonnie Avery, Ph.D., a key co-investigator and clinical professor of pharmaceutics at the college, identifies kratom’s alkaloids through chromatographic science methods, to determine where they go in the body and how they are broken down into genetic metabolites.
After that, McMahon and Jay McLaughlin, Ph.D., an associate professor of pharmacodynamics, order some in vivo pharmacodynamics tests to determine the health effects of individual alkaloids on receptor targets in the human brain.
The scientific team at the college will continue developing treatment strategies to detox addicts off opioids, similar in the way the classically accepted drugs, buprenorphine and methadone,which are more addictive and are currently prescribed. Although less addictive than heroin and other prescription opioids, they are narcotics with the potential to be abused, which is why university researchers are interested in safer alternatives to suboxone.
The last main research objective is for McCurdy to change a natural substance in kratom to reduce symptoms of opioid withdrawal.
CBD isolate only contains pure CBD and no other compounds. Full spectrum CBD gummies on the other hand contains CBD plus all the other compounds found in hemp such as THC, CBN, CBG etc. The amount of THC in full spectrum products is so low that you will not get the psychoactive high that is associated with it. Research shows there is more medicinal power behind CBD full spectrum products due to something called the entourage effect. All the cannabinoids work together. CBD by itself still has medicinal properties but the effective dose is narrow and limited. Hope this helps!
Can you elaborate on how it messed up your sleep, and whether it was full-spectrum or isolate? It could be that one will work better than the other for your specific ailment.
One thing I have noticed about CBD edibles products, even when they are similar product types and they come from reputable vendors, is that the effects vary dramatically. I think it comes down to each person’s metabolism, body chemistry, and endocannabinoid system, etc. For me this has meant tons of research and also experimentation to find out what works for me. So far I have found full-spectrum tinctures to be helpful for general well-being and calmness, full-spectrum vape carts/flower for bad pain or headaches, and isolate-based edibles for back pain and stuff where I want relief but also need to be really functional. But this differs quite a bit for each person!
Some other thoughts:
-You might give topicals a try if there are specific parts of your body that hurt (like hands and feet). There are some fairly affordable full-spectrum options out there.
-For some people, there are side effects that subside once their bodies get used to the CBD intake. Not saying you should tough it out if you aren’t seeing benefits, but if you are getting pain relief from CBD oil, you might try sticking with it for a bit to see if your sleep regulates after a while.
-Like I mentioned above, some folks get better results with isolate vs. full spectrum, or vice versa (general consensus is that full spectrum is king, but it’s not the case for everyone). Some people have reported that CBD isolate will make them feel more alert or even keep them up at night, so if you used isolate and had trouble sleeping that could be it.
-When in doubt, try smoking a tiny bit of flower from a reputable vendor and see if that helps! I save flower for very bad pain or intolerable headaches, but it works like a freaking charm, and fast too.
Sorry for the wall of text, still drinking my morning coffee and kind of scatterbrained. Hope some of this was helpful and hope you can find some relief!
Department of Pharmacology, University of Washington, Seattle, WA showed, “Given the promising results for CBD in treating anxiety and stress disorders, coupled with its low side-effect profile, we have analyzed its effects on epilepsy and anxiety-like behaviors in DS mice. Here we studied the best CBD oil for anxiety and stress, substantially reduces the frequency, duration, and severity of seizures and ameliorates the impaired social interaction behaviors of DS mice. These beneficial effects are correlated with enhanced GABAergic neurotransmission, decreased excitation/inhibition ratio, and decreased action potential firing of excitatory neurons in response to strong stimuli. These changes in GABAergic neurotransmission are mimicked and occluded by inhibition of the lipid-activated G protein-coupled receptor GPR55, suggesting that CBD’s effects are mediated, at least in part, by this signal transduction pathway. Our results strengthen basic science support for clinical use of CBD in DS and give initial clues to its physiological and molecular mechanisms of action.”
“In the current study we have found that while reducing EMVs, CBD also modulates mitochondrial function and the expression of mitochondrial associated proteins prohibitin and STAT3. Although studies on direct links between EMV release and mitochondrial changes are relatively limited, requiring further investigation, EMV generation has previously been linked to this organelle The slight variability in reduction of prohibitin in response to water soluble CBD products between the cancer cell lines tested here tallies in with the observed differences in effectivity of CBD to inhibit EMVs from these different cancer cells. A similar correlation was found between expression changes in STAT3 and inhibition of EMV release following CBD treatment, as both PC3 and HEPG2 cells showed more reduction in STAT3 levels following CBD treatment, alongside a more pronounced inhibitory effect on total EMV release, compared to MDA-MB-231 cells; which, while showing overall significant reduction in EMVs and reduced levels of STAT3 and prohibitin, these effects were somewhat less marked than in the other two cancer types.” Uchini S. Kosgodage at School of Human Sciences, London Metropolitan University, London, United Kingdom wrote, ” The EMV modulatory effects of CBD could thus be partly mediated by the above observed mitochondrial changes. In addition, CBD has also been shown for example to stimulate mitochondrial uptake of calcium, followed by a decrease and a matching sudden increase in intracellular calcium.”
There are likely very complex relationships also occurring between various Cannabinoids in Cannabis that may lead to certain medical efficacy. That is important to remember when considering the consumption of CBD for insomnia products that contain Cannabinoids. There is an attractiveness to isolating a specific chemical, researching it, patenting synthetic derivatives, and marketing specific drugs. That said, the relationships are complex, will likely take years to understand, and many patients I’ve met appear to find the most medical benefit from a diverse group of Cannabinoids whose interactions are not particularly well understand, but the results are hard to argue with.