Science Blog

Welcome to the mapper science blog

science of CBD

CBD and THC interact competitively at the receptor level, so it is true that CBD can lessen the “high” that THC causes.

Study from National Academy of Sciences published October 2017

Department of Pharmacology, University of Washington, Seattle, WA showed, “Given the promising results for CBD in treating anxiety and stress disorders, coupled with its low side-effect profile, we have analyzed its effects on epilepsy and anxiety-like behaviors in DS mice. Here we studied the best CBD oil for anxiety and stress, substantially reduces the frequency, duration, and severity of seizures and ameliorates the impaired social interaction behaviors of DS mice. These beneficial effects are correlated with enhanced GABAergic neurotransmission, decreased excitation/inhibition ratio, and decreased action potential firing of excitatory neurons in response to strong stimuli. These changes in GABAergic neurotransmission are mimicked and occluded by inhibition of the lipid-activated G protein-coupled receptor GPR55, suggesting that CBD’s effects are mediated, at least in part, by this signal transduction pathway. Our results strengthen basic science support for clinical use of CBD in DS and give initial clues to its physiological and molecular mechanisms of action.”

Frontiers in pharmacology published this research in August 2019

“In the current study we have found that while reducing EMVs, CBD also modulates mitochondrial function and the expression of mitochondrial associated proteins prohibitin and STAT3. Although studies on direct links between EMV release and mitochondrial changes are relatively limited, requiring further investigation, EMV generation has previously been linked to this organelle The slight variability in reduction of prohibitin in response to water soluble CBD products between the cancer cell lines tested here tallies in with the observed differences in effectivity of CBD to inhibit EMVs from these different cancer cells. A similar correlation was found between expression changes in STAT3 and inhibition of EMV release following CBD treatment, as both PC3 and HEPG2 cells showed more reduction in STAT3 levels following CBD treatment, alongside a more pronounced inhibitory effect on total EMV release, compared to MDA-MB-231 cells; which, while showing overall significant reduction in EMVs and reduced levels of STAT3 and prohibitin, these effects were somewhat less marked than in the other two cancer types.” Uchini S. Kosgodage at School of Human Sciences, London Metropolitan University, London, United Kingdom wrote, ” The EMV modulatory effects of CBD could thus be partly mediated by the above observed mitochondrial changes. In addition, CBD has also been shown for example to stimulate mitochondrial uptake of calcium, followed by a decrease and a matching sudden increase in intracellular calcium.”

There are likely very complex relationships also occurring between various Cannabinoids in Cannabis that may lead to certain medical efficacy. That is important to remember when considering the consumption of CBD for insomnia products that contain Cannabinoids. There is an attractiveness to isolating a specific chemical, researching it, patenting synthetic derivatives, and marketing specific drugs. That said, the relationships are complex, will likely take years to understand, and many patients I’ve met appear to find the most medical benefit from a diverse group of Cannabinoids whose interactions are not particularly well understand, but the results are hard to argue with.

Join the Conversation

1 Comment

Leave a comment

Your email address will not be published. Required fields are marked *